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Pura Muñoz-Cánoves

As seen in: Nature, Cell Press
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Articles

A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy

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By Silvia Campanario, Mercedes Grima-Terrén, Megan Rommelfanger, Stefania Dell’ Orso, Xuesong Feng, Andres Cisneros, Ignacio Ramírez-Pardo, Aina Calls-Cobos, Benjamin Yang, Kyung Dae Ko, Esther Garcia-Dominguez, Laura Pena-Couso, Grace Chih-Wen Chou, Yuewen Zheng, Nasun Hah, Davide Randazzo, Alberto Pérez-García, Tovah E. Markowitz, Jose Cesar Milisenda, Iago Pinal-Fernandez, Andrew L. Mammen, Mari Carmen Gómez-Cabrera, Antonio Serrano, Eusebio Perdiguero, Vittorio Sartorelli, Joan Josep Isern, Pura Muñoz-Cánoves
| Cell Press Verified
STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Rabbit anti-PCM1 (dilution 1:100) Sigma Aldrich Cat# HPA023370; RRID: AB_1855072 AF647 Rabbit anti-Laminin (dilution 1:200) Novus biologicals Cat# NB300-144AF647; RRID: AB_2891039 AF750 Rabbit anti-Laminin (dilution 1:100) Novus biologicals Cat# NB300-144AF750; RRID: AB_3186430 Rabbit anti-Ki67 (dilution 1:100) Abcam Cat# ab15580; RRID: AB_443209 Mouse anti-SV2 (dilution 1:200) DSHB Cat# AB_2315387; RRID: AB_2315387 Mouse anti-2H3...
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Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy - Nature Metabolism

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By Olaya Santiago-Fernández, Susmita Kaushik, Kristen Lindenau, Rabia R. Khawaja, Stefano Donega, Luigi Ferrucci, Julie A. Reisz, Angelo D’Alessandro, Pura Muñoz-Cánoves, Stefan Feske
| Nature Verified
Abstract Chaperone-mediated autophagy (CMA) contributes to proteostasis maintenance by selectively degrading a subset of proteins in lysosomes. CMA declines with age in most tissues, including skeletal muscle. However, the role of CMA in skeletal muscle and the consequences of its decline remain poorly understood. Here we demonstrate that CMA regulates skeletal muscle function.
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Circadian clock communication during homeostasis and ageing - Nature Reviews Molecular Cell Biology

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By Thomas Mortimer, Jacob Smith, Pura Muñoz-Cánoves
| Nature Verified
Abstract Maintaining homeostasis is essential for continued health, and the progressive decay of homeostatic processes is a hallmark of ageing. Daily environmental rhythms threaten homeostasis, and circadian clocks have evolved to execute physiological processes in a manner that anticipates, and thus mitigates, their effects on the organism. Clocks are active in almost all cell types; their rhythmicity and functional output are determined by a combination of tissue-intrinsic and systemic inputs.
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