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Pushkal Sharma

As seen in: BioRxiv
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Articles

Polyamines buffer labile iron to suppress ferroptosis

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By Pushkal Sharma, Heather R. Keys, Sebastian Müller, Ivan S. Pires
| BioRxiv
Abstract Polyamines are essential and evolutionarily conserved metabolites present at millimolar concentrations in mammalian cells. Cells tightly regulate polyamine homeostasis through complex feedback mechanisms, yet the precise role necessitating this regulation remains unclear. Here, we show that polyamines function as endogenous buffers of redox-active iron, providing a molecular link between polyamine metabolism and ferroptosis.
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Genetically encoded fluorescent reporter for polyamines

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By Pushkal Sharma, Colin Kim, Heather R. Keys, Shinya Imada
| BioRxiv
Abstract Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson's disease and cancer, driving interest in therapeutically targeting this pathway. However, measuring cellular polyamine levels, which vary across cell types and states, remains challenging.
Open in Who Shared Issue with article?

A genetically encoded fluorescent reporter for polyamines

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By Colin Kim, Heather R. Keys, Shinya Imada, Pushkal Sharma
| BioRxiv
Abstract Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson's disease and cancer, driving interest in therapeutically targeting this pathway. However, measuring cellular polyamine levels, which vary across cell types and states, remains challenging.
Open in Who Shared Issue with article?
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