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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Case Report: dupilumab for severe pruritus in pediatric recessive dystrophic epidermolysis bullosa—a longitudinal clinical assessment and literature review
Abstract Recessive dystrophic epidermolysis bullosa (RDEB) results from biallelic COL7A1 variants and causes trauma-induced blistering, scarring, and progressive extracutaneous complications. Severe pruritus may intensify skin injury through an itch-scratch cycle. We report a 7-year-old, 25-kg girl with infantile-onset generalized blistering, severe pruritus, mucosal and nail involvement, scarring, and digital contractures. Histopathology showed a subepidermal blister.
Decitabine suppresses triple-negative breast cancer by disrupting DNMT1 liquid-liquid phase separation and synergizes with G9a inhibition
Abstract Triple-negative breast cancer (TNBC) remains a substantial clinical challenge due to the lack of well-defined therapeutic targets. Previous studies have demonstrated that epigenetic modifiers play crucial roles in the progression of various cancers. In this study, we identify DNA methyltransferase 1 (DNMT1) as a critical epigenetic driver of TNBC proliferation and metastasis.
Food environment and cardiovascular kidney metabolic diseases mortality
Abstract Cardiovascular, kidney, and metabolic (CKM) diseases are leading causes of mortality in the United States (US), with geographic and socioeconomic disparities. The community food environment, including food accessibility and security, is a modifiable determinant of CKM health. We systematically examined associations between county-level multidimensional food environment indicators and CKM-related mortality across US counties.
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