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Qianying Ruan

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Articles

Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors

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By Yuting Cai, Angelika Dannert, Erez James Cohen, Yue Cheng, Tianran Li, Mengru Wang, Chuan Lan, Haizhen Fan, Zhicheng He, Qing Liu, Lujing Wang, Wenying Wang, Gehao Chen, Tunan Chen, Min Mao, Lixia Wang, Xiaoning Zhang, Yi Zhang, Xinyue Zhou, Jiayu Duan, Chunhua Luo, Qianying Ruan, Haoyue Qi
| Science Magazine Verified
Editor’s summary Penetrating the blood-brain barrier and activating the immune system are two main barriers of current therapies to treat primary and metastatic brain malignancies. Here, Cheng et al. evaluate repurposing ibrutinib, a blood-brain barrier penetrating the tyrosine kinase inhibitor (TKI) to target and activate its effect on tumor-associated macrophages (TAMs).
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