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Editor’s summary Penetrating the blood-brain barrier and activating the immune system are two main barriers of current therapies to treat primary and metastatic brain malignancies. Here, Cheng et al. evaluate repurposing ibrutinib, a blood-brain barrier penetrating the tyrosine kinase inhibitor (TKI) to target and activate its effect on tumor-associated macrophages (TAMs).
Keywords glioblastoma rabies virus neuro-glioma interaction diagonal band of Broca cholinergic input glutamatergic input neural circuit manipulation CHRM3 scopolamine donepezil Get full text access Log in, subscribe or purchase for full access. References 1. Mancusi, R. ∙ Monje, M. The neuroscience of cancer Nature. 2023; 618:467-479 2. Winkler, F. ∙ Venkatesh, H.S. ∙ Amit, M. ... Cancer neuroscience: State of the field, emerging directions Cell. 2023; 186:1689-1707 3.
1Biomedical Pioneering Innovation Center (BIOPIC), Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Peking University (PKU), Beijing, China 2Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China 3Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China 4Guangdong Provincial Key...
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