Qiaoli Li

To the Editor: TET2 mutations are among the most frequent genetic alterations in myelodysplastic neoplasms (MDS), but their prognostic significance remains controversial [1,2,3]. Previous studies suggest TET2 acquisition timing may shape clinical phenotypes and clonal evolution [4, 5], whereas biallelic TET2 inactivation has been associated with monocytosis, chronic myelomonocytic leukemia-like biology [6, 7], and possibly a distinct MDS subgroup enriched for splicing factor co-mutations [8].

Abstract Background: Acute thyrotoxic myopathy (ATM) is a relatively rare and severe complication of hyperthyroidism, mainly reported in individual cases and lacking standardized treatment protocols. Objective: This study evaluated the efficacy of glucocorticoids (GCs), adenosine triphosphate (ATP), and antithyroid drugs (ATDs) in treating ATM to guide clinical management.

Back to Journals » The Application of Clinical Genetics » Volume 19 Authors Zheng G, Xu C , Xie F, Li Q, Ou Z, Wang D, Li H Received 18 October 2025 Accepted for publication 31 December 2025 Published 22 January 2026 Volume 2026:19 Pages 1—10 DOI https://doi.org/10.2147/TACG.S573156 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.