Qingsong Yin
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Rovadicitinib, a first-in-class JAK/ROCK inhibitor, in patients with myelofibrosis: a preclinical and phase I study
Dear Editor, Myelofibrosis (MF) is the clinically most severe subcategory of myeloproliferative neoplasms (MPN), which can present as primary MF (PMF), or develop from the progression of polycythemia vera (PV) and essential thrombocythemia (ET; post-PV MF [PPV-MF] or post-ET MF [PET-MF]) [1]. Prominent clinical features in MF include bone marrow fibrous tissue hyperplasia, anemia, splenomegaly, and constitutional symptoms [1].
Upregulation of TCF1 and BCL11B in CD8+ effector T cells predicts favorable response to ibrutinib in patients with chronic lymphocytic leukemia
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Abstract The Bruton’s kinase inhibitor ibrutinib has become a cornerstone in the treatment of chronic lymphocytic leukemia (CLL). Previous studies reported an association between upregulation of TCF1 and BCL11B transcription factors with favorable survival outcomes in CLL patients. This study aimed to investigate the correlation of TCF1 and BCL11B with response to ibrutinib.
By Ge Liu, Taotao Liang, Shan Wang Verified, Xiaojiao Wang, Hongfei Wu, Qian Wang, Xiaojuan Liu, Jia Liu, Qingsong Yin, Songke Yin, Hongmian Zhao, Xiaodong Luv
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Nature
Verified
Efficacy and safety of short-course blinatumomab in patients with relapsed/refractory or MRD-positive B-cell acute lymphoblastic leukemia
To the Editor Blinatumomab has significantly improved survival in patients with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) [1,2,3], particularly those with measurable residual disease (MRD) positivity [4]. Recently, it has been integrated into first-line therapy of B-ALL patients [5,6,7].
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