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Olverembatinib plus immunotherapy versus olverembatinib plus allogeneic hematopoietic cell transplantation in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia
To the Editor: Philadelphia chromosome–positive (Ph⁺) acute lymphoblastic leukemia (ALL) accounts for approximately 20–30% of adult B-cell ALL cases [1]. Historically, Ph⁺ ALL has been associated with poor outcomes due to intrinsic chemoresistance. The integration of BCR::ABL1 tyrosine kinase inhibitors (TKIs) into frontline induction regimens has dramatically improved complete remission (CR) rates to >95%.
Efficacy and safety of short-course blinatumomab in patients with relapsed/refractory or MRD-positive B-cell acute lymphoblastic leukemia
To the Editor Blinatumomab has significantly improved survival in patients with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) [1,2,3], particularly those with measurable residual disease (MRD) positivity [4]. Recently, it has been integrated into first-line therapy of B-ALL patients [5,6,7].
Clinical characteristics of acute myeloid leukaemia patients with a large number of azurophilic granules: A single‐centre retrospective study
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interests. Supporting Information Filename Description bjh19494-sup-0001-TableS1.docxWord 2007 document , 14.8 KB Table S1. REFERENCES 1, , , . Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors. J Leukoc Biol. 2013; 94(4): 711–721. 2, , , , , , et al.
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