Qiurong Ding

Abstract Hepatic insulin resistance is central to the metabolic syndrome. Here we investigate the role of BTB and CNC homology 1 (BACH1) in hepatic insulin signaling. BACH1 is elevated in the hepatocytes of individuals with obesity and patients with non-alcoholic fatty liver disease (NAFLD).

‘Aging biomarkers’ refers to scientifically measurable parameters of the aging process; these are age-related changes at cellular, organ and organismal levels that can be applied to predict the transition into a pathological state1. Biomarkers can be classified into six categories: physiological characteristics; imaging traits; histological features; cellular alterations; molecular changes; and secretory factors.

Highlights • Constitutive depletion of Slc16a11 in mice causes minimal metabolic consequences • T2D-associated variants of SLC16A11 are not loss-of-function mutants • Mouse studies help to establish direct physiological causality from genotype to phenotype Summary Hoch et al. (2019) Hoch E. Florez J.C. Lander E.S. Jacobs S.B.R. Gain-of-function claims for type-2-diabetes-associated coding variants in SLC16A11 are not supported by the experimental data. Cell Rep.