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Target-guided Screening of Fragments (TGSOF) in the Discovery of Inhibitors against EV-A71 3C Protease

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By Ping Song, Shengjun Fu, Quandeng Nie, Yuying Ma
| Royal Society of Chemistry Verified
Target-guided screening of fragments (TGSOF) was developed and employed in the identification of EV-A71 3C protease (3Cpro) inhibitors. We identified 4-acetylpyridine and 3-acetylpyridine as effective P3 fragments of an inhibitor and obtained the corresponding irreversible inhibitors 12c and 12f via this method. Furthermore, based on 12c and 12f, we have obtained reversible inhibitors 17c and 17f.
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