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Plasma proteomics framework predicts metabolic dysfunction-associated steatotic liver disease up to 16 years before onset
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health challenge, yet preclinical identification remains difficult owing to a lack of reliable predictive tools. Here we show that a panel of five plasma proteins, FUOM, ACY1, KRT18, CDHR2 and GGT1, identified and validated across over 50,000 participants from the Southern UK, Northern UK, EPIC-Norfolk and Southern China cohorts, serves as a predictive signature for incident MASLD.
Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJuly 15, 2026 Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation Click to copy article linkArticle link copied! Lingbo Xu Lingbo Xu College of Pharmacy, Chongqing Medical University, Chongqing 400016, China Ruyi Huang Ruyi Huang College of Pharmacy, Chongqing Medical University, Chongqing 400016, China Basic Medicine Research and Innovation Center for Novel Target and Therapeutic...
VMP1 forms a Ca 2+ release channel essential for postnatal heartbeat
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Normal heart contraction requires synchronized calcium ion (Ca2+) release from the sarcoplasmic reticulum (SR), traditionally attributed to ryanodine receptor 2 (RyR2).
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