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Quanyin Hu on Muck Rack

Quanyin Hu

As seen in: Nature, Wiley Online Library, University of Wisconsin-Madison, ACS Publications, EurekAlert!, Science Magazine, Royal Society of Chemistry, New Atlas
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Articles

Macropinocytosis-mediated recyclable LYTACs (McR-TACs) for receptor-independent protein degradation

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By Peixin Liu, Tianyi Ma, Yawen You, Yu Chen, Quanyin Hu, Michelle Y. Cai
| Nature Verified
Abstract The degradation of cell membrane and extracellular proteins with lysosome-targeting chimeras (LYTACs) is limited by nonrecyclable, receptor-dependent mechanisms that shuttle proteins to lysosomes, restricting the broad use of this emerging technology. Here we developed a recyclable chimera composed of a polyzwitterion and protein of interest (POI) ligand for protein degradation.
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Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

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By Kaige Chen, Quanyin Hu
| Wiley Online Library Verified
1 Introduction Targeted chimeras (TACs) propose a class of engineered modalities designed to couple target recognition with high affinity to an active clearance process, which is referred to targeted protein degradation (TPD) [1, 2]. As the name suggests, TACs couple a target-binding module with a degradation-driving module, which converts the fate of the targeted protein of interest (POI).
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Scaffolds toughen bacteria-based therapy

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By Zhipeng Lin, Hanshen Tsai, Hinano Takase, Kaige Chen, Quanyin Hu
| Science Magazine Verified
Abstract References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Abstract Engineered cells can sense disease and deliver drugs at a site of pathology. These living therapeutics provide localized, self-sustaining responses to environmental changes, such as inflammation and pathogenic signals, that conventional drugs cannot offer (1, 2).
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