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Quinton Raymond Markett on Muck Rack

Quinton Raymond Markett

As seen in: Nature
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Antigen presentation by B cells enables epitope spreading across an MHC barrier - Nature Communications

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By Cecilia Fahlquist-Hagert, Thomas Wittenborn, Emily Yang, Gudrun Winther, Jinrong Huang, Johan Palmfeldt, Michael Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Kristian Savstrup Kastberg, Quinton Raymond Markett, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, John D. Nieland
| Nature Verified
Abstract Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE). The initiating clone did not need to enter germinal centers to precipitate epitope spreading. Rather, it localized to extrafollicular splenic bridging channels early in the response.
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