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Quirze Rovira on Muck Rack

Quirze Rovira

As seen in: Nature, BioRxiv, Cell Stem Cell, Genome Research
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Articles

PRKG1 hinders myogenic differentiation and predicts response to AKT inhibitor ipatasertib in Rhabdomyosarcoma - Nature Communications

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By Alex Cebria-Xart, Pau Berenguer-Molins, Júlia Perera-Bel, Juan Pablo Arcon, Suwipa Saen-Oon, Lucia Diaz Verified, Lucía Tello Díaz, Marina Gay, Marta Vilaseca, Quirze Rovira, Angel M. Carcaboso, Inmaculada Hernández-Muñoz, Pablo Táboas, Soledad Gómez-González, Ignasi Folch-I-Casanovas
| Nature Verified
Abstract Rhabdomyosarcoma (RMS) is marked by a myogenesis differentiation blockade, and while the AKT/mTOR pathway is universally activated, its pharmacological inhibition has shown limited success. Here, we evaluate the activity of pan-AKT inhibitors Ipatasertib, ATP-competitive, and Miransertib, allosteric inhibitor, in RMS cell lines and fusion-positive/negative patient-derived xenografts (PDX). Unlike Miransertib, Ipatasertib show significant antitumor activity against a subset of RMS.
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Specific photoreceptor cell fate pathways are differentially altered in NR2E3-associated diseases

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By Quirze Rovira, Noelia Díaz Verified, Izarbe Aísa-Marín, Laura Calvo-López
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression

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By Ni-Chen Chang, Quirze Rovira, Jonathan Wells Verified, Cédric Feschotte
| Genome Research
↵* Corresponding author; email: j.vaquerizas{at}lms.mrc.ac.uk Abstract There is considerable interest in understanding the effect of transposable elements (TEs) on embryonic development. Studies in humans and mice are limited by the difficulty of working with mammalian embryos, and by the relative scarcity of active TEs in these organisms.
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