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1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States of America 2USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, United States of America 3Childhood Complex Disease Genomics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States of America 4Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX,...
Abstract Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these factors are still unclear. One approach to distinguishing between alternative mechanisms is to study species that reproduce at very young ages, as competing hypotheses make different predictions about patterns of mutation in these organisms.
Abstract Understanding and treating human diseases require valid animal models. Leveraging the genetic diversity in rhesus macaque populations across eight primate centers in the United States, we conduct targeted-sequencing on 1845 individuals for 374 genes linked to inherited human retinal and neurodevelopmental diseases. We identify over 47,000 single nucleotide variants, a substantial proportion of which are shared with human populations.
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