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Opioids and long-term pain management: nursing considerations
Rachael Barton Senior lecturer, in continuing professional development, Medical School, Edge Hill University, Ormskirk, England Why you should read this article: • To be aware of the current evidence base for use of opioids in long-term pain management • To recognise the importance of opioid stewardship • To enhance your knowledge of best practice in optimising opioid management Evidence suggests that opioids are no longer appropriate for long-term use in chronic non-malignant pain, due to...
Petri dishes, phages, and public speaking - at the LAM ECS Research Symposium 2025
Rachael Barton and Luka Brajdić open up on their experiences of the Letters in Applied Microbiology ECS Symposium 2025 at the University of Liverpool on June 12. Applied Microbiology International held their fourteenth annual Letters in Applied Microbiology Early Career Scientist Research Symposium on June 12th, 2025.
Reductional Meiosis I Chromosome Segregation Is Established by Coordination of Key Meiotic Kinases
Highlights • Spo13 recruits Polo kinase to kinetochores to direct sister chromatid co-segregation • Kinetochore-associated Polo drives co-segregation independently of monopolin • Spo13 counteracts cohesin kinases to prevent premature loss of centromeric cohesion • Spo13 restricts CK1δ to allow shugoshin reaccumulation after meiosis I Summary Meiosis produces gametes through a specialized, two-step cell division, which is highly error prone in humans.
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