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Rachel Ni Earchai on Muck Rack

Rachel Ni Earchai

As seen in: BioRxiv, Cell Press
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Articles

Protein-free membrane fusion: A refined view of the delicate fusogenic properties of calcium

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By Matilde Accorsi, Rachel Ni Earchai, Naresh Yandrapalli, Shreya Pramanik, Rumiana Dimova
| Cell Press Verified
Significance Calcium is widely regarded as a potent, protein-free fusogen in nanometer-scale lipid vesicles, yet its relevance for fusion between cell-sized membranes remains unresolved. This gap limits our ability to translate decades of LUV-based fusion studies to more physiologically realistic systems and restricts the use of calcium in synthetic cell engineering.
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Protein-free membrane fusion: a refined view of the delicate fusogenic properties of calcium

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By Naresh Yandrapalli, Matilde Accorsi, Rachel Ni Earchai
| BioRxiv
Abstract In the late 20th century, calcium took on the identity of an independent fusogen, when it was found to induce fusion of anionic large unilamellar vesicles (LUVs), yet its ability to drive fusion in cell-sized membranes remains poorly understood.
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