Radhan Ramadass on Muck Rack

Radhan Ramadass

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Articles

Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis

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By Felix Gunawan, Ryuichi Fukuda, Radhan Ramadass, Arica Beisaw
| Cell Press Verified
Highlights • Mechanical forces from cardiac contractility positively regulate VCL in vivo • VCL interacts with actin regulators in cardiomyocytes in response to mechanical forces • VCL facilitates cardiomyocyte myofilament maturation through SSH1 and CFL • Zebrafish cfl1 mutants exhibit cardiomyocyte myofilament disruption Summary Mechanical forces regulate cell behavior and tissue morphogenesis.
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