Radiobiology Laboratory

Abstract Radiotherapy is considered as a second or third-line treatment for recurrent pituitary adenomas. As it is a benign tumor, the balance should clearly favor the benefit and induce the least amount of side effects. This retrospective study aims to evaluate the incidence of side effects after treatment and their actual causality with radiotherapy through dosimetric analysis.

RNA-Seq profiling was performed to compare 3 × 8 Gy delivered with photon or proton radiations with non-irradiated CT26 tumors, seven days after the last radiation fraction (Fig. 1A). For each contrast, genes differentially expressed exhibiting a fold change ≥ 2 between the irradiated and non-irradiated conditions were subjected to gprofiler2 to generate a functional enrichment list.

Loading metrics Open Access Peer-reviewed Research Article Citation: Riazi G, Brizais C, Garali I, Al-rifai R, Quelquejay H, Monceau V, et al. (2024) Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm. PLoS ONE 19(8): e0308273.