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Ragadeepthi Tunduguru on Muck Rack

Ragadeepthi Tunduguru

As seen in: The Journal of Biological Chemistry
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Articles

The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells

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By Ragadeepthi Tunduguru, Arianne Aslamy, Vishal A. Salunkhe
| The Journal of Biological Chemistry Verified
Defects in translocation of the glucose transporter GLUT4 are associated with peripheral insulin resistance, preclinical diabetes, and progression to type 2 diabetes. GLUT4 recruitment to the plasma membrane of skeletal muscle cells requires F-actin remodeling. Insulin signaling in muscle requires p21-activated kinase-1 (PAK1), whose downstream signaling triggers actin remodeling, which promotes GLUT4 vesicle translocation and glucose uptake into skeletal muscle cells.
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