Raïssa Houmadi on Muck Rack

Raïssa Houmadi

As seen in: Nature, Science Magazine, Cell Press
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Articles

LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity - Nature Communications

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By Raïssa Houmadi, Claire Lacouture, Valérie Duplan-Eche, Nicolas Destainville
| Nature Verified
Abstract T-cell cytotoxic function relies on the cooperation between the highly specific but poorly adhesive T-cell receptor (TCR) and the integrin LFA-1. How LFA-1-mediated adhesion may scale with TCR stimulation strength is ill-defined. Here, we show that LFA-1 conformation activation scales with TCR stimulation to calibrate human T-cell cytotoxicity.
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3-D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System (MANTIS)

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By Raïssa Houmadi, Jeremy Martin, Nadine Serhan, Manon Scholaert
| biorxiv.org
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse

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By Raïssa Houmadi, Delphine Guipouy, Javier Rey-Barroso, Zilton Vasconcelos
| Cell Press Verified
Decreased Killing Potential and Reduced LFA-1 Activation in WAS CD8+ T Cells Aberrant Actin Cytoskeleton Dynamics and Non-radial Spreading in WAS CD8+ T Cells Biased Distribution of LFA-1 Clusters in WAS T Cells WASP Controls LFA-1 Organization and Activation at the Cellular and Nanometric Scales WASP Is Required to Confine Lytic Granules at the CTL Synapse In this study, we set out to explore the precise topography of LFA-1 at the immunological synapse of WAS patient-derived CD8+ T cells. A...
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