Rajan K C

Abstract De novo mutations in transcriptional regulators are emerging as key risk factors contributing to the etiology of neurodevelopmental disorders. Human genetic studies have recently identified ZMIZ1 and its de novo mutations as causal of a neurodevelopmental syndrome strongly associated with intellectual disability, autism, ADHD, microcephaly, and other developmental anomalies. However, the role of ZMIZ in brain development or how ZMIZ1 mutations cause neurological phenotypes is unknown.

Abstract Angiogenesis is a highly coordinated process involving the control of various endothelial cell behaviors. Mechanisms for transcription factor involvement in the regulation of endothelial cell dynamics and angiogenesis have become better understood, however much remains unknown, especially the role of non-DNA binding transcriptional cofactors.

Loading metrics Open Access Peer-reviewed Research Article Citation: K. C. R, Patel NR, Shenoy A, Scallan JP, Chiang MY, Galazo MJ, et al. (2024) Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function. PLoS ONE 19(5): e0302926. https://doi.org/10.1371/journal.pone.0302926 Editor: Kenji Tanigaki, Shiga Medical Center, JAPAN Received: August 25, 2023; Accepted: April 15, 2024; Published: May 8, 2024 Copyright: © 2024 K. C. et al.