Rajani Maiya

1 INTRODUCTION Current evidence indicates that protein kinase C epsilon (PKCε) regulates ethanol consumption, preference, intoxication and reward, and anxiety like behaviour.

Highlights • Central amygdala CRF neurons release GABA and several neuropeptides • Preventing GABA release in these neurons suppresses basal anxiety-like behavior • Knockdown of CRF or dynorphin prevents anxiety evoked by chemogenetic activation • CRF or dynorphin knockdown reduces but neurotensin knockdown enhances fear learning Summary Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning.

Research Articles, Systems/Circuits Matthew B. Pomrenze, Jorge Tovar-Diaz, Angelo Blasio, Rajani Maiya, Simone M. Giovanetti, Kelly Lei, Hitoshi Morikawa, F. Woodward Hopf and Robert O. Messing Journal of Neuroscience 6 February 2019, 39 (6) 1030-1043; DOI: https://doi.org/10.1523/JNEUROSCI.2143-18.2018 Abstract The central amygdala (CeA) is important for fear responses to discrete cues.