Ramapraba Appanna on Muck Rack

Ramapraba Appanna

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Articles

CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

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By Angéline Rouers, Marion Chevrier, Josephine Lum, Ramapraba Appanna
| Cell Press Verified
Highlights • CD27highCD38high plasmablasts from patients with dengue form three clusters • Clusters 0/1 express high levels, and more dengue-specific, antibodies • Clusters 0/1 are reminiscent of extrafollicular activation • Clusters 2 and 3 are metabolically active with an expression footprint of T cell help Summary Clinically important broadly reactive B cells evolve during multiple infections, with B cells re-activated after secondary infection differing from B cells activated after a...
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