Ramón Treviño

Cite Jump to ExpandCollapse ArticleJune 25, 2026 Tricomponent α-Carbonyl Alkylation by a Cobalt-Catalyzed Polar–Radical and Radical–Polar Crossover Cascade Click to copy article linkArticle link copied! Yangyang Wang Yangyang Wang Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, P. R.

Abstract Molecular shape is a key determinant of the structural properties and intermolecular interactions of privileged scaffolds, such as biaryl and oligoaryl compounds, which are widely used in the design of drugs, catalysts, and functional materials. Despite the well-recognized importance of molecular shape diversity and increased three-dimensionality, the chemical space of biaryl compounds remains dominated by linear and disk-like structures featuring para and meta substitution patterns.

Introduction Hydrogen atom transfer (HAT) has emerged as a major strategy for the functionalization of carbon–hydrogen bonds with applications in medicinal chemistry, materials science, and organic synthesis.[1-9] This strategy enables efficient introduction of diverse functionalities and obviates ancillary multistep synthetic manipulations.