William Thompson on Muck Rack

William Thompson

Indianapolis
As seen in: Nature, Wiley Online Library, Cambridge University Press & Assessment, PLOS Medicine, MDPI, SAGE Publishing, Scientific American, Taylor & Francis Online, ACS Publications, JAMA: Journal of the American Medical Association and
Physical Therapist. Professor. Bone Biologist. Learner of Learning.
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Articles

Cyclic sulfone ring remodeling enables molecular shape diversity-oriented synthesis of privileged biaryl and oligoaryl motifs

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By Viet D. Nguyen, Sachchida Nand, Ramón Treviño Verified, Arka Porey, William Thompson, Graham C. Haug, Seth O. Fremin, Shree Krishna Dhakal, William Hughes, Dylan Moran, Johant Lakey-Beitia, Chandan Giri, Samuel G. Greco, Hadi Arman, Oleg V. Larionov, Patrick Manning-Lorino
| Nature Verified
Abstract Molecular shape is a key determinant of the structural properties and intermolecular interactions of privileged scaffolds, such as biaryl and oligoaryl compounds, which are widely used in the design of drugs, catalysts, and functional materials. Despite the well-recognized importance of molecular shape diversity and increased three-dimensionality, the chemical space of biaryl compounds remains dominated by linear and disk-like structures featuring para and meta substitution patterns.
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Motor cortex directly excites the substantia nigra pars reticulata, the basal ganglia output nucleus

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By William Thompson, Sten Grillner, Gilad Silberberg, Patryk Wekwejt
| Nature Verified
Abstract Inhibitory neurons of the substantia nigra pars reticulata (SNr) serve as a primary output through which the basal ganglia regulate behavior. Using a virally targeted optogenetic approach, combined with whole cell patch-clamp recordings of SNr neurons, we show that, in mice, projection neurons of both primary and secondary motor cortices (M1 and M2) form monosynaptic excitatory connections onto different subpopulations of GABAergic SNr neurons.
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Phosphorylation-Dependent Charge Transport in Biomolecular Junctions of Major Histocompatibility Complex Phosphopeptides Click to copy article link Article link copied!

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By William Thompson, Jennifer Burrows, Reihaneh Safavi-Sohi
| dx.doi.org
1. Introduction Click to copy section linkSection link copied! Understanding charge transport across proteins is critical for several reasons, ranging from fundamental biological processes in many living organisms to biosensors and bioelectronic applications. (1−5) Electron transport through biomolecules underpins a variety of essential biological processes, including respiration, photosynthesis, and enzymatic catalysis.
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