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Highlights • Yor1-ΔF shows synthesis defects when Sec61 or EMC function is compromised • Synthesis defects are suppressed by ribosomal and RQC mutants • Translation initiation is a second point of potential regulation • Pre-emptive quality control on the ER might protect the cell from aberrant proteins Summary Cells possess multiple mechanisms that protect against the accumulation of toxic aggregation-prone proteins.
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