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1 INTRODUCTION Human evolution has been marked by a major increase in our ancestors' cognitive and behavioral abilities, underlined by brain morphological expansion (González-Forero & Gardner, 2018; Neubauer et al., 2018; Püschel et al., 2024). As a highly metabolic organ, the brain needs an abundant supply of oxygen and, at rest, most of its ATP comes from oxidative metabolism of glucose (Mintun et al., 2001).
Abstract Human embryonic bone and joint formation is determined by coordinated differentiation of progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory factors that underlie lineage commitment of these cells remain elusive.
Highlights • 3D imaging reveals the developmental sequence of human head organs during gestation • Salivary gland morphogenesis is asymmetric and shows interindividual variability • Virtual reality and interactive 3D tools improve our understanding of human development • Hudeca.com, a web interface and image database to explore and learn human embryology Summary The evolution and development of the head have long captivated researchers due to the crucial role of the head as the gateway for...
Abstract Human limbs emerge during the fourth post-conception week as mesenchymal buds, which develop into fully formed limbs over the subsequent months1. This process is orchestrated by numerous temporally and spatially restricted gene expression programmes, making congenital alterations in phenotype common2.
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