Christopher Buckley on Muck Rack

Christopher Buckley

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Articles

The embryonic origins of site-specific arthritis

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By Sarah Davidson, Davide L. Simone, Kathrin U Jansen, Max Cowan, Caio Machado, Ian Reekie, Ananya Bhalla, Rowie Borst, Cesar Medina Verified, Joshua A. Bull, Zhi Yi Wong, Sarah Hill, Micon Garvilles, Sam Pledger, Patricia Reis Nisa, Dylan Windell, Moustafa Attar, Andrew J. Bodey, Alissa L Parmenter, Helen Byrne, Sharif U. Ahmed, Shashidhara Marathe, Peter Lee, Chris Mahony, Adam P Croft, Stephen N. Sansom, Mark Coles, Christopher Buckley, Nora Rebecca Schwingen
| Nature Verified
Abstract The cellular basis for site-specific inflammation remains unclear. In human fingers, proximal interphalangeal (PIP) joints are preferentially affected by inflammatory arthritis, whereas distal interphalangeal joints are spared, providing a model to investigate the predilection of inflammation to distinct sites.
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Tissue resident memory T cells populate the human uveal tract

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By Andrew D. Foers, Ian Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas Buckley Verified, Moustafa Attar, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, Imran Masood, Mark Coles, Jonathan P. Sherlock, Andrew Dick, Sarah E. Coupland, Stephen N. Sansom, David Copland, Christopher Buckley, Srilakshmi Sharma, Soledad Aguilar-Munoa
| Nature Verified
Abstract The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues. In immune-mediated inflammatory diseases, such as psoriasis and rheumatoid arthritis, tissue resident T cells trigger disease flares in the skin and joints.
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Tissue Damage in Rheumatoid Arthritis is Genetically linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

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By Kevin Sheridan, College Dublin, College Dublin Ireland, Emma R. Dorris, Matthew Fisher, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher Buckley, Anthony Wilson, Maria Inês Pimenta, Jemma Falkov, Sam Pledger, Hector Devey
| Wiley Online Library Verified
Supporting Information Filename Description art70123-sup-0001-Disclosureform.pdfPDF document, 647.7 KB Disclosure Form art70123-sup-0002-FigureS1.tifTIFF image, 5.8 MB Supplementary Data Fig 1. Demonstration of mouse siPAM efficiency in N2A cells A) Western blot and B) densitometry of PAM protein in N2A cells following a 72 h transfection with siNTC or siPAM. Treatment with siPAM knocked down PAM expression 67% (10 nM) and 51% (30 nM).
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