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Articles by Rasheed Ahmad
Hospital Type and Clinical Outcomes for Pediatric Lower-Extremity Open Fracture: Implications for Child Health Services Organizations
KEY WORDS Pediatric open fractures lower-extremity fractures Children’s hospitals pediatric trauma care health care utilization fracture fixation methods Abbreviations AIS (Abbreviated injury scale) aOR (Adjusted odds ratio) CI (Confidence interval) ECH (Exclusively children’s hospitals) GA (Gustilo-Anderson) HCAI (Heath Care Access and Information) ICD-10-CM (Internal Classification of Diseases, 10th Revision, Clinical Modification) ICD-10-PCS (Internal Classification of Diseases, 10th...
Exploring the multifaceted roles of beta-defensins in prediabetes: a detailed review
Abstract Prediabetes represents a critical window of immune–metabolic dysregulation during which insulin resistance, low-grade inflammation, and barrier dysfunction emerge before overt diabetes. Human β-defensins (HBDs), classically described as antimicrobial peptides, are increasingly recognized as modulators of epithelial integrity, inflammatory signaling, and host–microbiota interactions process central to early metabolic deterioration.
Assessment of climatic parameter variation and its impact on sustainable agriculture in Dir Upper Pakistan with mitigation and adaptation strategies - Scientific Reports
Abstract Climate change poses a significant threat to agricultural sustainability, particularly in vulnerable mountainous regions such as Upper Dir, Pakistan. This study, titled "Analysis of Variation in Climatic Parameters and Their Impact on Sustainable Agriculture in Dir, Pakistan: Mitigation and Adaptation Strategies," aims to assess past climatic trends (2002–2023) and project future scenarios using the high-emission Representative Concentration Pathway (RCP 8.5) model.
Optimizing New Water Infrastructure With Design‐Phase Digital Twins
Layout imagery by Gorodenkoff/stock.adobe.com While cloud-based technologies and Industry 4.0 adoption are helping to broadly drive change globally, the water sector lags behind other industries in terms of digital transformation. One promising approach to bridge this gap is the use of digital twins.
ہم ایک ایسی دنیا میں جی رہے ہیں جہاں لب سِل چکے ہیں اور کان بہرے ہو چکے ہیں۔ نہ کوئی سننے کو تیار…
ہم ایک ایسی دنیا میں جی رہے ہیں جہاں لب سِل چکے ہیں اور کان بہرے ہو چکے ہیں۔ نہ کوئی سننے کو تیار ہے، نہ کوئی سمجھنے کو۔ بےحسی اتنی گہری ہو چکی ہے کہ درد چیخ بھی اٹھے تو کوئی پلٹ کر دیکھنے کی زحمت نہیں کرتا۔ ہم نے ہمیشہ اپنے جذبات اور مفادات کو مقدم رکھا، اور دوسروں کے دکھ ہمارے لیے محض ایک گزرتی ہوئی خبر بن کر رہ گئے۔ ہم سٹیٹس کی دنیا کے قیدی بن چکے ہیں، جہاں چند سیکنڈز میں اپنے غم کہے جا سکتے ہیں یا دوسروں کے دیکھے جا سکتے ہیں۔ مگر یہ احساس کا زوال نہیں تو اور کیا ہے؟ جذبات کا کھلے عام قتل...
Types Of Satellites in the Space
RASHEED AHMAD · Follow 3 min read · -- What we have in space today can also be referred to as satellites and these are categorized by their functions, their orbits as well as design. Here are some of the main types: Communication Satellites Used for transmitting television, radio, internet and telephone services respectively. They are preferably located in geosynchronous orbits They are located geostationary orbits which orbit the Earth at the same rate as the Earth rotates. 2.
Technology
RASHEED AHMAD · Follow 3 min read · -- Technology has changed significantly from the past many years and new technologies tend to camouflage the old systems. Here’s a comparison of some key aspects: 1. Speed and Efficiency Old Tech:** The classic approaches to computing and devices, such as the earlier generations of central processing units and hard disks, may have operational speed as well as task execution issues.
Life Improve From Amazon Online Business
RASHEED AHMAD · Follow 3 min read · -- The decision of starting an Amazon business choosing online marketing as a key activity can positively affect people’s life in many aspects. 1. Financial Growth: Marketing products online also helps in increasing the visibility of your product such that they reach as many people as possible. Advertising means people will buy your products and hence increase your sales so that you can get financial freedom. 2.
Appeal courts or courts of intermediate of USA
RASHEED AHMAD · Follow 2 min read · -- Appeal courts or courts of intermediate appeal refers to a form of jurisdiction that lies between trial courts or courts banking on higher courts. Almost all the States in the U.S has formed these courts to deal with civil appeals from inferior trial courts thereby easing the burden of the state supreme court. These courts mainly act as appellate courts, they must ensure that the trial courts got their facts and law right to a certain extent.
Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels - Nature Communications
Abstract Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the endogenous FAHFA hydrolase androgen induced gene 1 (AIG1) in adipocytes.
Engineers often need a lot of water to keep data centers cool
By Rasheed Ahmad, Ph.D., P.E., M.ASCE Data centers are increasing in number and in their environmental footprint — especially in terms of water demand. This primer explores how such facilities present new opportunities and challenges for civil engineers.
Wish I'd Known: Engineer learns membership has its rewards
By Rasheed Ahmad, Ph.D., P.E., M.ASCE I wish I’d known earlier in my career the importance of and the benefits to being involved in professional societies such as ASCE. When I studied environmental engineering at Georgia Tech in the early 1990s, I was not a student member of ASCE. I didn’t join the Society until 2000, which was four years after I graduated. Even then I was not very involved.
Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans | Nature Communications
Abstract Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, counters metabolic stress and promotes healthy aging in C. elegans.
Unveiling the potential pleiotropic effects of metformin in treating COVID-19: a comprehensive review
Introduction Coronavirus disease 2019 (COVID-19), a global pandemic caused by the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has impacted millions of individuals across the globe (Atzrodt et al., 2020). People with pre-existing conditions like type 2 diabetes (T2D) are at a higher risk of experiencing severe outcomes from COVID-19 (Al-Kuraishy et al., 2021; Kamyshnyi et al., 2021).
Metabolic Inflammation and Cellular Immunity
Metabolic and immune cell responses are intimately linked and cross-regulated.
Designing Y-shaped two-dimensional (2D) polymer-based donor materials with addition of end group acceptors for organic and perovskite solar cells - Journal of Molecular Modeling
Abstract Context For the advancement in fields of organic and perovskite solar cells, various techniques of structural alterations are being employed on previously reported chromophores. This way, molecules with all the properties desired for better performance of solar cells can be achieved. In this regard, theoretical modeling of chromophores has gained quite an interest due to its ability to save time, resources, and money.
Correction to: Impact of end‑group modifications and planarity on BDP‑based non‑fullerene acceptors for high‑performance organic solar cells by using DFT approach (pdf) | Paperity
Journal of Molecular Modeling, Feb 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s00894-022-05403-5.pdf Saeed, Muhammad Umar, Hadia, N. M. A., Iqbal, Javed, Hessien, M. M., Shawky, Ahmed M., Ans, Muhammad, Alatawi, Naifa S., Khera, Rasheed Ahmad. , Journal of Molecular Modeling, 2023, pp. 1, Volume 29, Issue 3, DOI: 10.1007/s00894-022-05403-5
Cysteine dioxygenase type 1: A new player in adipose physiology and metabolic health
Commentary for: “Adipose tissue cysteine dioxygenase type 1 is associated with an anti-inflammatory profile, impacting on systemic metabolic traits” Obesity is growing at epidemic proportions and looms as an alarming menace to global human health and wellbeing.
Models versus Datasets: Reducing Bias through Building a Comprehensive IDS Benchmark
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Neutral sphingomyelinase‐2 and cardiometabolic diseases
Summary Sphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ß‐cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, nonalcoholic steatohepatitis, and cancer.
Trends : Zoomshaira: Not Just a New Name for Traditional Mushaira
Home > Magazine > Features > Trends : Zoomshaira: Not Just a New Name for Traditional Mushaira By Dr. Rasheed Ahmad March 2021 Can virtual mushairas replace the traditional form, letting the audience and poets enjoy the immersive poetry experience that has been the hallmark of these conclaves?
The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation
IntroductionObesity-mediated low-grade chronic inflammation plays a key role in the development of various diseases, including type 2 diabetes, atherosclerosis, and hepatic steatosis. In obesity, adipose tissue is dysregulated by the infiltration of immune cells, associated with increased production of cytokines and chemokines.
The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation
The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation Rasheed Ahmad, Areej Al-Roub, Shihab Kochumon, Nadeem Akther, Reeby Thomas, Manju Kumari, Merin S. Koshy, Ali Tiss, Yusuf A. Hannun, Jaakko Tuomilehto, Sardar Sindhu, Evan D. Rosen The Journal of Immunology April 9, 2018, ji1701552; DOI: 10.4049/jimmunol.1701552
US Water Regulations and India's Water Challenges
References AWWA, 2016. AWWA India Addressing the Country's Water Supply Challenges. Opflow, 42: 1: 10. http://doi.org/10.5991/OPF.2016.42.0001. , 2013. The Clean Water Act at 40. Harvard University, Oct 2012. http://blogs.harvard.edu/testelp/files/2013/03/ (accessed February 2016). IMF (International Monetary Fund), 2016. India and the IMF. www.imf.org/external/country/IND/index.htm (accessed October 2016). , 2014. The Whole to the Part: Can Regulations Fix the Big Jig-Saw Puzzle of Indian Waters? Proc.
Increased expression of IRF-5 in the adipose tissue in obesity: Implication in metabolic inflammation
Obesity is marked by a state of chronic low-grade inflammation called metabolic inflammation which plays a role in the development of insulin resistance and type-2 diabetes (T2D). We and others have shown that the innate immune toll-like receptors (TLRs) are involved in metabolic inflammation/insulin resistance. The transcription factor called interferon regulatory factor (IRF)-5 is a major regulator of proinflammatory macrophage polarization; however, its role in obesity/T2D remains unclear.
Palmitate-induced MMP-9 expression in the human monocytic cells: Significance in metabolic inflammation
Matrix metalloproteinase (MMP)-9 is predominantly produced by monocytes/macrophages and directs the infiltration of circulatory immune cells into the adipose tissue through damage of vascular endothelial basement membrane. Obese individuals are known to have increased MMP-9 plasma levels and MMP-9 is reported to play an important role in obesity-mediated adipose tissue inflammation.
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