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Rathipriya Viswanathan on Muck Rack

Rathipriya Viswanathan

As seen in: Cell Reports
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Conserved disordered regions and ubiquitin-binding motifs within HUWE1 contribute to substrate targeting plasticity

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By Xuezhen Ge, Fulin Jiang, Chumo Chen, Aida Husain, Eric Bennett, Caesar A. De La Fuente, Trivikram Rajkhowa, Rathipriya Viswanathan
| Cell Reports Verified
Results HUWE1 has been reported to target a broad range of substrates, including transcription factors, kinases, and other regulatory proteins.32,42 However, our previous work suggested that many HUWE1 substrates are cell type-specific.26 To identify a set of HUWE1 substrates that can be used to interrogate HUWE1 function across different cell and tissue types, we quantified proteome-wide protein abundance changes upon HUWE1 disruption across multiple cell lines.
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