Ravikiran Kasula

Abstract SNARE-mediated secretory vesicle (SV) exocytosis underpins neuronal communication. Munc18-1 orchestrates SNARE complex formation by controlling the opening of syntaxin-1A. How the SV-plasma membrane interface becomes fusion-competent at the nanoscale level is poorly understood. Here, we propose that the interaction of Munc18-1 with VAMP2 during vesicular docking triggers nanoscale re-organization which renders the SV-plasma membrane interface fusion-competent.

Research Article View ORCID ProfileRachel S. Gormal, View ORCID ProfilePranesh Padmanabhan, Ravikiran Kasula, View ORCID ProfileAdekunle T. Bademosi, View ORCID ProfileSean Coakley, Jean Giacomotto, View ORCID ProfileAilisa Blum, View ORCID ProfileMerja Joensuu, Tristan P. Wallis, Harriet P. Lo, Srikanth Budnar, James Rae, Charles Ferguson, Michele Bastiani, Walter G. Thomas, View ORCID ProfileEls Pardon, Jan Steyaert, Alpha S. Yap, View ORCID ProfileGeoffrey J. Goodhill, View ORCID ProfileMassimo A.