Rebecca G Castle

Abstract Biomarkers that predict response to combined radiation and anti-PD-1 therapy in clear cell renal cell carcinoma (ccRCC) are poorly defined. RAPPORT trial (NCT02855203) is a prospective phase I/II study of stereotactic ablative body radiotherapy (SABR) and pembrolizumab in 30 patients with oligometastatic ccRCC.

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Abstract Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity, however, how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of a gamma-delta T cell receptor (γδ) in complex with BTN member 2A1 (BTN2A1) revealed that BTN2A1 engages the side of the γδ TCR, leaving the apical TCR surface bioavailable. We reveal that BTN3A1 is a second γδ TCR ligand, that co-engages γδ TCR via binding to this accessible apical surface.