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Sean MacDonald

  • Founder, Hot Damn! Creative
Long Beach
As seen in: MSN, Yahoo Life, Nature, Los Angeles Times, WIRED Magazine, The Globe and Mail, JAMA Oncology, Ad Age, Jalopnik, Popular Mechanics and
Tweets include but are not limited to: bad television, taco reviews, hip hop hot takes, the nba, shinfo, and motorcycle racing.
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Articles

Dynamic immune profiling predicts response to radiation plus anti-PD-1 therapy in oligometastatic renal cell carcinoma

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By Van To, Niko Thio, Rebecca G Castle, Sean MacDonald, Tristan Molden-Hauer, James Wells, Ryan McMahon, Mathias Bressel, Ben Tran, Arun A. Azad, Daniel Moon, Sree Appu, Lih-Ming Wong, Declan Murphy, David B. Pryor, Lavinia Spain, Lewis Au, Criselle D’Souza, Paul Neeson, Shankar Siva, Katharine Cuff
| Nature Verified
Abstract Biomarkers that predict response to combined radiation and anti-PD-1 therapy in clear cell renal cell carcinoma (ccRCC) are poorly defined. RAPPORT trial (NCT02855203) is a prospective phase I/II study of stereotactic ablative body radiotherapy (SABR) and pembrolizumab in 30 patients with oligometastatic ccRCC.
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Tumor-resident T cells and dendritic cells form an in situ archetype during immunotherapy response in melanoma

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By Andrea Di Pietro, Lewis Au, Niko Thio, Angela Pizzolla, Thu Nguyen, Thu Nguyễn, Sean MacDonald, Hugh Chalmers, Ruiqing Zhu, Marina Bacac, Petra C. Schwalie, Mitchell Levesque, Karen L Winch, Joanna Chan, George Yeung, Lavinia Spain, Aparna Rao, Shahneen Sandhu, David E Gyorki, Grant McArthur Verified, Laura K. Mackay, Paul Neeson, Patrick Crock, Alessia Airaghi, Tristan Molden-Hauer, Ramona Schlenker, Sonia Mailer, Kristy Barnes-Cullen
| Nature Verified
Abstract Tumor-resident (TR) T cells, known as tissue-resident memory (TRM) T cells in mice, play a central role in melanoma immunosurveillance, yet their contribution to immune checkpoint inhibitor (ICI) therapy has not been comprehensively explored. We performed spatial and single-cell profiling on 32 metastatic melanoma lymph node samples, from treatment-naïve, ICI-resistant and ICI-responsive patients. Here we show that tumor areas in ICI-responders were enriched for both CD8+ and CD4+ TR.
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Metastasis-directed Therapy With or Without Pembrolizumab for Oligometastatic Clear Cell Renal Cell Carcinoma: Pooled Analysis of Two Prospective Single-arm Phase 2 Trials

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By Alexander D. Sherry, Van To, Criselle D’Souza, Simin Kiany, Niko Thio, Suyu Liu, Xiaowen Sun, Sean MacDonald, Haesun Choi, Aaron Rains SEO, Kieko Hara, David B. Pryor, Arun A. Azad, Ben Tran, Lewis Au, Lavinia Spain, Ethan B Ludmir, Eric Jonasch, Becky Castle
| European Urology Verified
Keywords Stereotactic body radiation therapy Kidney cancer Oligometastasis Metastasis-directed therapy Renal cell carcinoma Get full text access Log in, subscribe or purchase for full access. References 1. Tang, C. ∙ Msaouel, P. Charting the path to systemic therapy de-escalation-oligometastatic kidney cancer as a paradigm JAMA Oncol. 2024; 10:561-562 2. Hannan, R. ∙ Christensen, M. ∙ Christie, A. ... Stereotactic ablative radiation for systemic therapy–naïve oligometastatic kidney cancer Eur Urol Oncol.
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