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Reese C. Guitche on Muck Rack

Reese C. Guitche

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Articles

Genome-scale perturb-seq in primary human CD4 + T cells maps context-specific regulators of T cell programs and human immune traits

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By Ronghui Zhu, Emma Dann, Jun Yan, Justine Reyes Retana, Ryunosuke Goto, Reese C. Guitche, Lillian Brixi, Mineto Ota, Austin Hartman, Theodore L. Roth, Ansuman T. Satpathy, Jonathan Pritchard, Alexander Marson
| Cell Press Verified
Results To map functional GRNs systematically in human primary T cells, we compiled a genome-scale library targeting a union of all expressed genes in human CD4+ T cells and all transcription factors (12,779 genes in total; STAR Methods). Using an optimized high-titer lentiviral production protocol we developed previously,6 we achieved transduction efficiencies of CRISPRi machinery up to 90% (Figure S1).
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