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Regulatory RNAs

As seen in: PLOS Biology, Cell Press
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Articles

Long noncoding RNAs: p53’s secret weapon in the fight against cancer?

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By Regulatory RNAs, Ashish Lal, Emily Dangelmaier, Sarah B. Lazar
| PLOS Biology Verified
Loading metrics Emily Dangelmaier , Sarah B. Lazar , Ashish Lal Emily Dangelmaier, Sarah B. Lazar, Ashish Lal Published: February 13, 2019 https://doi.org/10.1371/journal.pbio.3000143 Figures Abstract p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53.
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A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels

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By Ritu Chaudhary, Regulatory RNAs, Ioannis Grammatikakis, Bruna R. Muys
| asm.org
Research Article | Spotlight Ritu Chaudhary, Bruna R. Muys, Ioannis Grammatikakis, Supriyo De, Kotb Abdelmohsen, Xiao Ling Li, Yuelin Zhu, Swapna Vidhur Daulatabad, Dimitrios Tsitsipatis, Paul S. Meltzer, Myriam Gorospe, Sarath Chandra Janga, Ashish Lal DOI: 10.1128/MCB.00473-19 ABSTRACT Circular RNAs (circRNAs) are a class of noncoding RNAs produced by a noncanonical form of alternative splicing called back-splicing.
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When Long Noncoding Becomes Protein Coding

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By Regulatory RNAs, Ashish Lal
| asm.org
Minireview Corrine Corrina R. Hartford, Ashish Lal DOI: 10.1128/MCB.00528-19 ABSTRACT Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible. Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding. Numerous lncRNAs have been found to contain short open reading frames (sORFs) which have been overlooked because of their small size.
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