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Reinout A Bem on Muck Rack

Reinout A Bem

As seen in: Thorax
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Articles

Local dornase alfa treatment reduces NETs-induced airway obstruction during severe RSV infection

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By Bart Cortjens, Rineke de Jong, Judith G Bonsing, Reinout A Bem
| Thorax Verified
Respiratory syncytial virus (RSV) infection is characterised by airway obstruction with mucus plugs, containing DNA networks in the form of neutrophil extracellular traps (NETs). We investigated the effect of dornase alfa on histopathological NETs-induced airway obstruction and viral load in an age-relevant calf model of severe bovine RSV disease. As compared with the control animals, dornase alfa treatment resulted in a strong reduction of NETs-induced airway obstruction.
Open in Who Shared Issue with article?

Local dornase alfa treatment reduces NETs-induced airway obstruction during severe RSV infection

|
By Bart Cortjens, Reinout A Bem, Rineke de Jong, Judith G Bonsing
| Thorax Verified
Respiratory syncytial virus (RSV) infection is characterised by airway obstruction with mucus plugs, containing DNA networks in the form of neutrophil extracellular traps (NETs). We investigated the effect of dornase alfa on histopathological NETs-induced airway obstruction and viral load in an age-relevant calf model of severe bovine RSV disease. As compared with the control animals, dornase alfa treatment resulted in a strong reduction of NETs-induced airway obstruction.
Open in Who Shared Issue with article?
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By Reinout A Bem, Martin C Kneyber
| secure.jbs.elsevierhealth.com
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