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Reneau Castore

As seen in: BioRxiv
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Articles

The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages

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By Magdalena Circu, Reneau Castore, Brian Latimer Verified, Stephanie R. Shames
| BioRxiv
Abstract Legionella pneumophila is an environmental Gram-negative bacterium that parasitizes unicellular protozoa and can cause severe pulmonary infections when aerosolized bacteria are inhaled by humans. One critical aspect of Legionella pathogenesis is the establishment in the cytosol of infected macrophages of a unique ER-derived vacuole, that requires a sustained supply of host lipids during expansion.
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The intracellular growth of the vacuolar pathogen Legionella pneumophila is dependent on the acyl chain composition of host membranes

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By Ashley Wilkins, Benjamin Schwarz, Ascencion Torres-Escobar, Reneau Castore
| BioRxiv
Abstract Legionella pneumophila is an accidental human bacterial pathogen that infects and replicates within alveolar macrophages causing a severe atypical pneumonia known as Legionnaires disease. As a prototypical vacuolar pathogen L. pneumophila establishes a unique endoplasmic reticulum (ER)—derived organelle within which bacterial replication takes place.
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