Reni Kitte on Muck Rack

Reni Kitte

As seen in: MDPI, Cell Press
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Articles

Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation

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By Reni Kitte, Robert Serfling, Ulrich Blache, Claudius Seitz
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Open in Who Shared View Duplicates (159) Issue with article?

Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering

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By Reni Kitte, Martin Rabel, Reka Geczy, Stella Park
| Cell Press
Engineered T cells expressing chimeric antigen receptors (CARs) have been proven as efficacious therapies against selected hematological malignancies. However, the approved CAR T cell therapeutics strictly rely on viral transduction, a time- and cost-intensive procedure with possible safety issues. Therefore, the direct transfer of in vitro transcribed CAR-mRNA into T cells is pursued as a promising strategy for CAR T cell engineering.
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