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Rhea J. Longley on Muck Rack

Rhea J. Longley

Bangkok, Melbourne
As seen in: Nature, MDPI, Pursuit, Cell Press, The New Daily, The Journal of Immunology, Journal of Infection
Postdoc scientist @WEHI_research. @UniofOxford DPhil and @UTAS_ BMedRes. #immunology #parasitology #womeninstemm. Mum to 🧒 👶. Views my own.
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Articles

Protective immunity to clinical malaria is modified by the genetic diversity of P. falciparum antigens

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By Myo T Naung, Paolo Bareng, Papua New Guinea, Maria Ome-Kaius, Ramin Mazhari, Rhea J. Longley, Somya Mehra, Wilson Wong, Moses Laman, Benson Kiniboro, James Beeson, Eizo Takashima, Hikaru Nagaoka, Shannon Takala-Harrison, Takafumi Tsuboi, Leanne Robinson, Pascal Michon
| Journal of Infection Verified
Keywords clinical malaria naturally acquired immunity genetic diversity antigenic diversity transmission Plasmodium falciparum Papua New Guinea Introduction Malaria remains a significant global health challenge, especially in sub-Saharan Africa, where around 95% of malaria cases and deaths occur [1]. In 2023, approximately 263 million people were infected with malaria worldwide, leading to over 597,000 deaths.
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A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria

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By D. Herbert Opi, Rhea J. Longley, Eizo Takashima, Tim Spelman, Yanie Tayipto, Kael Schoffer, Jessica Brewster, Linda Reiling, Bruce D. Wines, Benson Kiniboro, Peter Siba, Matthias Harbers, Mark Hogarth, Takafumi Tsuboi, Leanne Robinson, Ivo Mueller, James Beeson
| Cell Press Verified
Results To quantify target-specific functional antibodies relevant to protective immunity, we developed a high-throughput bead-based multiplex assay using the Luminex xMAP technology, allowing us to measure FcγR-binding and complement-fixing antibodies to multiple P. vivax antigens simultaneously. P. vivax recombinant antigens were coupled to magnetic microspheres at optimized concentrations.
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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes - Nature Communications

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By Pailene S LIm, Xiao Xiao, Matthew J Grigg, Jetsumon Sattabongkot, Andrew Leis, Rhea J. Longley, Manoj T. Duraisingh, Jean Popovici, Danny Wilson, Alan F. Cowman
| Nature Verified
Abstract Invasion of erythrocytes by members of the Plasmodium genus is an essential step of the parasite lifecycle, orchestrated by numerous host-parasite interactions. In P. falciparum Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms the essential PCRCR complex which binds basigin on the erythrocyte surface. Rh5 is restricted to P. falciparum and its close relatives; however, PTRAMP, CSS and Ripr orthologs are present across the Plasmodium genus.
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