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Articles

Gcn5-Mediated Histone Acetylation Governs Nucleosome Dynamics in Spermiogenesis

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By Greg Donahue, Enrique Lin-Shiao, Richard Rangel, Lacey J. Luense
| Cell Press Verified
Highlights • ATAC-seq localizes retained nucleosomes to promoters and repetitive DNA in sperm • Gcn5-mediated histone acetylation is necessary for proper spermiogenesis • Gcn5 loss alters chromatin dynamics leading to increased histone retention in sperm • Gcn5 is necessary for normal sperm formation and male fertility in mice Summary During mammalian spermatogenesis, germ cell chromatin undergoes dramatic histone acetylation-mediated reorganization, whereby 90%–99% of histones are evicted.
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