Riet De Rycke

Abstract Aberrant intestinal epithelial cell (IEC) death is common in inflammatory bowel disease (IBD) and related animal models. While various cell death pathways contribute to disease, the dominant modalities and their regulatory mechanisms in intestinal inflammation remain ill defined.

Highlights • Autophagy intensifies prior to developmental cell death in the Arabidopsis root cap • The role of autophagy in cell death is divergent depending on the root cap cell type • Autophagy is dispensable for cell death and corpse clearance in the lateral root cap • Autophagy deficiency delays cell death and blocks corpse clearance in the columella Summary 1 Marshall R.S. Vierstra R.D. Autophagy: the master of bulk and selective recycling. Annu. Rev. Plant Biol.

We previously reported on the generation of the trivalent Nanobody called TROS that binds and inhibits human TNFR1 (hTNFR1), but without cross-reactivity to mouse TNFR1. To study the therapeutic potential of TROS, we generated human TNFRSF1A transgenic (hTNFR1 Tg) mice in a mouse TNFR1 KO-background.