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Articles by Rishu Guo
Human IgE monoclonal antibodies in the design of a novel in vitro model of the effector phase of peanut allergy
10% of US residents have food allergies, including 1% with peanut and/or tree nut allergy. Mast cell mediators released during the allergy effector phase drive allergic symptoms. Thus, there is a critical need for food allergy therapeutics targeting mast cells.
High‐ and low‐dose oral immunotherapy similarly suppress pro‐allergic cytokines and basophil activation in young children
1 INTRODUCTION Oral immunotherapy (OIT) has been used in research settings for the past decade and is now being evaluated in a Phase III clinical trial in subjects with peanut allergy.
Sublingual immunotherapy effective and safe treatment for peanut allergy
Organisation: Position: Deadline Date: Location: Sublingual immunotherapy, a new treatment for peanut, could offer patients a safe and effective way to protect themselves from severe allergic reactions or even anaphylaxis, found a study partly funded by the National Institutes of Health. People allergic to peanuts may have a new way to protect themselves from severe allergic reactions to accidental peanut exposure.
Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization
An estimated 6% to 8% of children are affected by food allergy,1x1Sicherer, S.H. and Sampson, H.A. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014; 133: 291–308 Abstract | Full Text | Full Text PDF | PubMed | Scopus (685) | Google ScholarSee all References, 2x2Iweala, O.I., Choudhary, S.K., and Commins, S.P. Food allergy. Curr Gastroenterol Rep.
High and Low Dose Oral Immunotherapy Similarly Suppress Pro‐Allergic Cytokines and Basophil Activation in Young Children
Objective: We aimed to determine the immunologic changes caused by peanut OIT in preschool aged children and determine the effect on these immune responses in groups ingesting low or high dose peanut OIT (300 mg or 3000 mg, respectively) as maintenance therapy. Blood was drawn at several time points throughout the OIT protocol and PBMCs isolated and cultured with peanut antigens.
Food-specific IgG4 is associated with eosinophilic esophagitis
Article in Press Food-specific IgG4 is associated with eosinophilic esophagitisPublication HistoryPublished Online: April 01, 2016 Purchase this article (PDF Included) © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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