Rivka Lim

Highlights The World Health Organization (WHO) has recently published a draft definition of a persistent schistosomiasis hotspot, referring to, in brief, a location which satisfies specific prevalence and treatment intervention targets, but where transmission persists.

Results In mice infected with blood stage recently mosquito-transmitted P. chabaudi AS parasites, expressing GFP ( rMT-PcAS-GFP), parasitaemia peaked 9 days post infection (p.i.) at a low to moderate density (median 1.32%, IQR 0.53-4.27, n=51) (Figure 1), in line with expectations (Spence et al., 2013). There were no significant changes in weight compared to uninfected mice, but hemoglobin concentrations declined on day 11 p.i., as observed previously (Marr et al., 2020).