Rob Beagrie on Muck Rack

Rob Beagrie

United Kingdom
As seen in: Nature
@WellcomeTrust Sir Henry Dale Fellow based at @HumanGeneticsOx, interested in chromatin disruption in human disease. He/him. Mastodon: rbeagrie@qoto.org
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Articles

Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis - Nature Communications

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By Alexandra Preston, Joe Frost, Megan Teh, Mohsin Badat, Andrew Armitage, Sarah K. Wideman, Christian Babbs, Bart Ghesquière, James Davies Verified, Linda Sinclair, Jim Hughes, Mira Kassouf, Rob Beagrie, Douglas R. Higgs
| Nature Verified
Abstract Red blood cell development from erythroid progenitors requires profound reshaping of metabolism and gene expression. How these transcriptional and metabolic alterations are coupled is unclear. Nprl3 (an inhibitor of mTORC1) has remained in synteny with the α-globin genes for >500 million years, and harbours most of the a-globin enhancers. However, whether Nprl3 serves an erythroid role is unknown.
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