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Joe Frost

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Articles

TOX drives CD4+ TH1 effector function, antitumor immunity and autoimmune pathology - Nature Immunology

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By Andrew Scott, Paul Zumbo, Simon Grassmann, Joe Frost, Joseph C. Sun, Doron Betel, Andrea Schietinger, Brianna Naizir
| Nature Verified
Abstract TOX is a nuclear factor critical for thymic development of CD4+ thymocytes, natural killer and innate lymphoid cells. In post-thymic antigen-specific CD8+ T cells, TOX is highly expressed in settings of chronic antigen encounter such as cancer and chronic infection and required for the persistence of exhausted CD8+ T cells. The role of TOX in CD4+ T cells is less clear. Here, we show that TOX is critical for CD4+ type 1 helper T (TH1) cell differentiation.
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Opposing functions of distinct regulatory T cell subsets in colorectal cancer

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By Xiao Huang, Dan Feng, Sneha Mitra, Emma S Andretta, Nima Hooshdaran, Aazam P. Ghelani, Eric Wang, Joe Frost, Victoria R. Lawless, Aparna Vancheswaran, Qingwen Jiang, Cheryl Mai, Karuna Ganesh, Christina Leslie, Alexander Y. Rudensky
| Cell Press Verified
Keywords Treg cells heterogeneity CRC metastasis IL-10 IL-17 Introduction Regulatory T (Treg) cells, expressing the transcription factor Foxp3, are essential for organismal physiology and fitness. Parallel to the effector arm of adaptive immunity, they patrol the organism through recirculation and residence in secondary lymphoid organs and seed non-lymphoid tissues, including gastrointestinal and genital tracts, skin, and airways.
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Thanks, Newcastle, for being the brightest light in my darkest day Original

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By Joe Frost
| Newcastle Herald Verified
Joe Frost shares his search for answers in the podcast Forgotten Bombs: Bali 2005. Picture by Peter Lorimer I spent the morning of October 2, 2005, at Sanglah, the largest hospital in Bali. It was brutal. Subscribe now for unlimited access. or signup to continue reading All articles from our website & app The digital version of Today's Paper Crosswords, Sudoku and Trivia There had been 18 of us from Newcastle on Jimbaran Beach the night before. Then it was chaos.
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