“In breast cancer now, all of our treatment for hormone receptor–positive metastatic disease is a bit of a moving target because of new therapies that are available,” explains Hope S. Rugo, MD, division chief of breast medical oncology and the Women’s Cancers Program director at the City of Hope Comprehensive Cancer Center in Duarte, California. She discusses the “ever-changing” landscape involving the PI3 kinase/AKT/mTOR pathway with Robert A.