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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Temporomandibular disorders (TMD) pain is the most common orofacial pain with limited effective treatments.
240 Years of Excellence. 24 Hours of Giving Back. In honor of the school’s founding year, we’ve set a goal of 1,781 gifts in 24 hours. If we meet that goal, we unlock an additional gift of $1.781 million to The Exeter Fund from a generous group of alumni and parents. Every gift counts! For 240 years, Exeter’s core mission to unite goodness and knowledge and inspire youth from every quarter to lead purposeful lives has never waned.
Highlights • ERRα upregulates MPC1 expression to facilitate pyruvate entry into mitochondria • ERRα inhibition introduces exploitable metabolic vulnerabilities into cancer cells • Inhibition of ERRα increases reliance on glutamine oxidation and PPP to maintain NADPH • ERRα antagonists increase the efficacy of GLS1 and G6PD inhibitors Summary Most cancer cells exhibit metabolic flexibility, enabling them to withstand fluctuations in intratumoral concentrations of glucose (and other nutrients)...
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