Robert te Poele on Muck Rack

Robert te Poele

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Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy - Nature Communications

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By Joseph A. Newman, Nergis Imprachim, Paul Clarke Verified, Mohammad Hossain, Hans J. Oh, Paul Workman, Opher Gileadi, Robert te Poele
| Nature Verified
Abstract Brachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. Brachyury is minimally expressed in healthy tissues, making it a potential therapeutic target. Unfortunately, as a ligandless transcription factor, brachyury has historically been considered undruggable.
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