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Rochelle Hines

As seen in: Nature, Frontiers, The Conversation, The Daily Beast, Medical Xpress, Inverse, Philly Voice, Idaho Press
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Articles

Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes - Nature Neuroscience

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By Mahreen Khan, Christopher Pearson, Rochelle Hines, Maurice S. Swanson, Adam Ciesiołka, Katarzyna Taylor
| Nature Verified
Abstract Genome-wide enrichment of gene-specific tandem repeat expansions has been linked to autism spectrum disorder. One such mutation is the CTG tandem repeat expansion in the 3′ untranslated region of the DMPK gene, which is known to cause myotonic muscular dystrophy type 1. Although there is a clear clinical association between autism and myotonic dystrophy, the molecular basis for this connection remains unknown.
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Enrichment analysis of phenotypic data for drug repurposing in rare diseases

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By Rafael Gonzalez-Cano, Rochelle Hines, Psycho Genics, Zhuangzhi Zhang
| Frontiers
Alberto Ambesi-Impiombato* Kimberly Cox Sylvie Ramboz Daniela Brunner Mukesh Bansal† Emer Leahy PsychoGenics, Paramus, NJ, United States Drug-induced Behavioral Signature Analysis (DBSA), is a machine learning (ML) method for in silico screening of compounds, inspired by analytical methods quantifying gene enrichment in genomic analyses.
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Flip a switch and shut down seizures?

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By Rochelle Hines
| The Daily Beast Verified
By Rochelle Hines, Assistant Professor of Psychology, University of Nevada, Las Vegas The brain is a precision instrument. Its function depends on finely calibrated electrical activity triggering the release of chemical messages between neurons. But sometimes the brain’s careful balance is knocked out of control, as in epilepsy.
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